Pesquisa | Secretaria de Estado da Saúde

1.

Embracing cancer complexity: Hallmarks of systemic disease.

Swanton, Charles; Bernard, Elsa; Abbosh, Chris; André, Fabrice; Auwerx, Johan; Balmain, Allan; Bar-Sagi, Dafna; Bernards, René; Bullman, Susan; DeGregori, James; Elliott, Catherine; Erez, Ayelet; Evan, Gerard; Febbraio, Mark A; Hidalgo, Andrés; Jamal-Hanjani, Mariam; Joyce, Johanna A; Kaiser, Matthew; Lamia, Katja; Locasale, Jason W; Loi, Sherene; Malanchi, Ilaria; Merad, Miriam; Musgrave, Kathryn; Patel, Ketan J; Quezada, Sergio; Wargo, Jennifer A; Weeraratna, Ashani; White, Eileen; Winkler, Frank; Wood, John N; Vousden, Karen H; Hanahan, Douglas.

Cell ; 187(7): 1589-1616, 2024 Mar 28.

Artigo Inglês | MEDLINE | ID: mdl-38552609

2.

The next big questions in cancer research.

Loi, Sherene; Settleman, Jeffrey; Joyce, Johanna A; Pramesh, C S; Bernards, Rene; Fan, Jia; Merchant, Juanita L; Moslehi, Javid; Sellers, William R.

Cell ; 186(8): 1523-1527, 2023 04 13.

Artigo Inglês | MEDLINE | ID: mdl-37059060

3.

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

Wang, Liqin; Leite de Oliveira, Rodrigo; Huijberts, Sanne; Bosdriesz, Evert; Pencheva, Nora; Brunen, Diede; Bosma, Astrid; Song, Ji-Ying; Zevenhoven, John; Los-de Vries, G Tjitske; Horlings, Hugo; Nuijen, Bastiaan; Beijnen, Jos H; Schellens, Jan H M; Bernards, Rene.

Cell ; 173(6): 1413-1425.e14, 2018 05 31.

Artigo Inglês | MEDLINE | ID: mdl-29754815

4.

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

Workman, Paul; Draetta, Giulio F; Schellens, Jan H M; Bernards, René.

Cell ; 168(4): 579-583, 2017 02 09.

Artigo Inglês | MEDLINE | ID: mdl-28187281

5.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Vecchione, Loredana; Gambino, Valentina; Raaijmakers, Jonne; Schlicker, Andreas; Fumagalli, Arianna; Russo, Mariangela; Villanueva, Alberto; Beerling, Evelyne; Bartolini, Alice; Mollevi, David G; El-Murr, Nizar; Chiron, Marielle; Calvet, Loreley; Nicolazzi, Céline; Combeau, Cécile; Henry, Christophe; Simon, Iris M; Tian, Sun; in 't Veld, Sjors; D'ario, Giovanni; Mainardi, Sara; Beijersbergen, Roderick L; Lieftink, Cor; Linn, Sabine; Rumpf-Kienzl, Cornelia; Delorenzi, Mauro; Wessels, Lodewyk; Salazar, Ramon; Di Nicolantonio, Federica; Bardelli, Alberto; van Rheenen, Jacco; Medema, René H; Tejpar, Sabine; Bernards, René.

Cell ; 165(2): 317-30, 2016 Apr 07.

Artigo Inglês | MEDLINE | ID: mdl-27058664

6.

A missing link in genotype-directed cancer therapy.

Bernards, René.

Cell ; 151(3): 465-8, 2012 Oct 26.

Artigo Inglês | MEDLINE | ID: mdl-23101617

7.

MED12 controls the response to multiple cancer drugs through regulation of TGF-ß receptor signaling.

Huang, Sidong; Hölzel, Michael; Knijnenburg, Theo; Schlicker, Andreas; Roepman, Paul; McDermott, Ultan; Garnett, Mathew; Grernrum, Wipawadee; Sun, Chong; Prahallad, Anirudh; Groenendijk, Floris H; Mittempergher, Lorenza; Nijkamp, Wouter; Neefjes, Jacques; Salazar, Ramon; Ten Dijke, Peter; Uramoto, Hidetaka; Tanaka, Fumihiro; Beijersbergen, Roderick L; Wessels, Lodewyk F A; Bernards, René.

Cell ; 151(5): 937-50, 2012 Nov 21.

Artigo Inglês | MEDLINE | ID: mdl-23178117

8.

EGFR activation limits the response of liver cancer to lenvatinib.

Jin, Haojie; Shi, Yaoping; Lv, Yuanyuan; Yuan, Shengxian; Ramirez, Christel F A; Lieftink, Cor; Wang, Liqin; Wang, Siying; Wang, Cun; Dias, Matheus Henrique; Jochems, Fleur; Yang, Yuan; Bosma, Astrid; Hijmans, E Marielle; de Groot, Marnix H P; Vegna, Serena; Cui, Dan; Zhou, Yangyang; Ling, Jing; Wang, Hui; Guo, Yuchen; Zheng, Xingling; Isima, Nikita; Wu, Haiqiu; Sun, Chong; Beijersbergen, Roderick L; Akkari, Leila; Zhou, Weiping; Zhai, Bo; Qin, Wenxin; Bernards, René.

Nature ; 595(7869): 730-734, 2021 07.

Artigo Inglês | MEDLINE | ID: mdl-34290403

9.

Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers.

Jansen, Robin A; Mainardi, Sara; Dias, Matheus Henrique; Bosma, Astrid; van Dijk, Emma; Selig, Roland; Albrecht, Wolfgang; Laufer, Stefan A; Zender, Lars; Bernards, René.

Proc Natl Acad Sci U S A ; 121(9): e2319492121, 2024 Feb 27.

Artigo Inglês | MEDLINE | ID: mdl-38377196

10.

The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.

Dias, Matheus H; Liudkovska, Vladyslava; Montenegro Navarro, Jasmine; Giebel, Lisanne; Champagne, Julien; Papagianni, Chrysa; Bleijerveld, Onno B; Velds, Arno; Agami, Reuven; Bernards, René; Ciesla, Maciej.

EMBO Rep ; 2024 Apr 10.

Artigo Inglês | MEDLINE | ID: mdl-38600345

11.

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.

Wang, Hui; Yuan, Shengxian; Zheng, Quan; Zhang, Sisi; Zhang, Qianqian; Ji, Shuyi; Wang, Wei; Cao, Ying; Guo, Yuchen; Yang, Xupeng; Geng, Haigang; Yang, Fan; Xi, Shuijun; Jin, Guangzhi; Zhang, Jianming; Gao, Qiang; Bernards, René; Qin, Wenxin; Wang, Cun.

Gastroenterology ; 2024 Jan 21.

Artigo Inglês | MEDLINE | ID: mdl-38262581

12.

It's diagnostics, stupid.

Bernards, René.

Cell ; 141(1): 13-7, 2010 Apr 02.

Artigo Inglês | MEDLINE | ID: mdl-20371338

13.

Radical Sabbaticals.

Clevers, Hans; Firestein, Stuart; Ringrose, Leonie; Bernards, Rene; Darwin, K Heran; Vance, Russell E.

Cell ; 163(4): 788-9, 2015 Nov 05.

Artigo Inglês | MEDLINE | ID: mdl-26544929

14.

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Hölzel, Michael; Huang, Sidong; Koster, Jan; Ora, Ingrid; Lakeman, Arjan; Caron, Huib; Nijkamp, Wouter; Xie, Jing; Callens, Tom; Asgharzadeh, Shahab; Seeger, Robert C; Messiaen, Ludwine; Versteeg, Rogier; Bernards, René.

Cell ; 142(2): 218-29, 2010 Jul 23.

Artigo Inglês | MEDLINE | ID: mdl-20655465

15.

Inducing and exploiting vulnerabilities for the treatment of liver cancer.

Wang, Cun; Vegna, Serena; Jin, Haojie; Benedict, Bente; Lieftink, Cor; Ramirez, Christel; de Oliveira, Rodrigo Leite; Morris, Ben; Gadiot, Jules; Wang, Wei; du Chatinier, Aimée; Wang, Liqin; Gao, Dongmei; Evers, Bastiaan; Jin, Guangzhi; Xue, Zheng; Schepers, Arnout; Jochems, Fleur; Sanchez, Antonio Mulero; Mainardi, Sara; Te Riele, Hein; Beijersbergen, Roderick L; Qin, Wenxin; Akkari, Leila; Bernards, René.

Nature ; 574(7777): 268-272, 2019 10.

Artigo Inglês | MEDLINE | ID: mdl-31578521

16.

Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy.

Nowak-Sliwinska, Patrycja; van Beijnum, Judy R; Griffioen, Christian J; Huinen, Zowi R; Sopesens, Nadine Grima; Schulz, Ralph; Jenkins, Samir V; Dings, Ruud P M; Groenendijk, Floris H; Huijbers, Elisabeth J M; Thijssen, Victor L J L; Jonasch, Eric; Vyth-Dreese, Florry A; Jordanova, Ekaterina S; Bex, Axel; Bernards, René; de Gruijl, Tanja D; Griffioen, Arjan W.

Angiogenesis ; 26(2): 279-293, 2023 05.

Artigo Inglês | MEDLINE | ID: mdl-36459240

17.

RNAi Delivers Insights into Liver Cancer.

Bernards, René.

Cell ; 135(5): 793-5, 2008 Nov 28.

Artigo Inglês | MEDLINE | ID: mdl-19041743

18.

Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.

Huijberts, Sanne C F A; Boelens, Mirjam C; Bernards, Rene; Opdam, Frans L.

Br J Cancer ; 124(1): 176-182, 2021 01.

Artigo Inglês | MEDLINE | ID: mdl-33204026

19.

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

van Brummelen, Emilie M J; Huijberts, Sanne; van Herpen, Carla; Desar, Ingrid; Opdam, Frans; van Geel, Robin; Marchetti, Serena; Steeghs, Neeltje; Monkhorst, Kim; Thijssen, Bas; Rosing, Hilde; Huitema, Alwin; Beijnen, Jos; Bernards, Rene; Schellens, Jan.

Oncologist ; 26(4): 290-e545, 2021 04.

Artigo Inglês | MEDLINE | ID: mdl-33296125

20.

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.

Wang, Cun; Wang, Hui; Lieftink, Cor; du Chatinier, Aimee; Gao, Dongmei; Jin, Guangzhi; Jin, Haojie; Beijersbergen, Roderick L; Qin, Wenxin; Bernards, René.

Gut ; 69(4): 727-736, 2020 04.

Artigo Inglês | MEDLINE | ID: mdl-31519701

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Embracing cancer complexity: Hallmarks of systemic disease.

The next big questions in cancer research.

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

A missing link in genotype-directed cancer therapy.

MED12 controls the response to multiple cancer drugs through regulation of TGF-ß receptor signaling.

EGFR activation limits the response of liver cancer to lenvatinib.

Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers.

The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.

Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.

It's diagnostics, stupid.

Radical Sabbaticals.

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

Inducing and exploiting vulnerabilities for the treatment of liver cancer.

Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy.

RNAi Delivers Insights into Liver Cancer.

Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.